Product Name: Salicylazosulfapyridine
CAS No.: 599-79-1
Melting point: 260-265 °C (dec.)(lit.)
Solubility: NH4OH 1M: 50 mg/ml, clear, red
Solubility inwater, at 25 C: <0.1 g/100 ml
Appearance: white powder
Sulfasalazine was developed in the 1950s specifically to treat rheumatoid arthritis. It was believed at the time that bacterial infections were the cause of rheumatoid arthritis. Sulfasalazine is a sulfa drug, a derivative of mesalazine, and is formed by combining sulfapyridineand salicylate with an azo bond. It may be abbreviated SSZ.
It is on the World Health Organizations List of Essential Medicines, a list of the most important medication needed in a basic health system.
See also Disease-modifying antirheumatic drugs for its role in rheumatoid arthritis
Sulfasalazine is used in the treatment of inflammatory bowel disease, including ulcerative colitis and Crohns disease. It is also indicated for use in rheumatoid arthritis and used in other types of inflammatory arthritis (e.g. psoriatic arthritis) where it has a beneficial effect. It is often well tolerated compared to other DMARDs.
In clinical trials for the treatment of chronic alcoholics, sulfasalazine has been found to reverse the scarring associated with liver cirrhosis. A study at Newcastle University found that the drug may act to aid the healing of cirrhosis of the liver. Cells called myofibroblasts, which contribute to scar tissue in a diseased liver, also appear to secrete proteins that prevent the breakdown of the scar tissue. Sulfasalazine appears to retard this secretion.
It is usually not given to children under 2 years of age.
The use of sulfasalazine in inflammatory bowel disease has declined due mainly to the fact that it yields the metabolitesulfapyridine which gives rise to side-effects such as agranulocytosis and hypospermia. However, the other metabolite of sulfasalazine, 5-aminosalicyli
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Salicylazosulfapyridine Powder Active Pharmaceutical Ingredients Raw Materials Images