Product Name: Probucol
Molecular Formula: C31 H48 O2 S2
Batch Molecular Weight: 516.84
Physical Appearance: White crystalline solid
Minimum Purity: >99%
Storage: Desiccate at +4°C
Probucol is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease.
However, clinical trials were stopped after it was found that it may lower HDL in patients with a previous history of heart disease.
Probucol was initially developed in the 1970s by a chemical company to maximize airplane tire longevity. Probucol is associated with QT interval prolongation.
Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.
Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant which inhibits the oxidation of cholesterol in LDLs; this slows the formation of foam cells, which contribute to atherosclerotic plaques.
Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions. Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.
Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane. In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.
||Nandrolone Decanoate (DECA)
||Nandrolone Phenypropionate (NPP)
||Boldenone Undecylenate (Equipoise)
||Drostanolone Propionate (Masteron)
||Methenolone Acetate (Primobolan)
||Trenbolone Hexahydrobenzyl Carbonate
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Store in cool and dry area and keep away from direct sunlight.oC
2 years, keep in formal storage condition.
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API Probucol Powder Pharma Raw Materials CAS 23288-49-5 White Appearance Images