Pharmaceutical Grade Promethazine Hydrochloride For Treating Allergy CAS:58-33-3
Basic information:
Chemical name: Promethazine hydrochloride
MF: C17H21ClN2S
MW: 320.88
CAS: 58-33-3
Purity: 99%
Appearance: White powder
HS code: 29343000
Package: 25kg
COA:
Product name |
promethazine hydrochloride |
CAS No. |
58-33-3 |
Outer Packing |
25KG/DRUM |
Production date |
APRIL 2016 |
Shelf life |
MARCH 2021 |
Standard adopted |
IP |
Items of analysis |
Specification |
Results |
description |
a white or faintly yellowish,crystalline powder |
a white crystalline powder |
solubility |
very soluble in water,freely soluble in chloroform and in ethanol(95%),practically insoluble in ether |
very soluble in water,freely soluble in chloroform and in ethanol(95%);practically insoluble in ether |
A. IR absorption spectrum |
positions and relative sizes of the banks in the spectrum of the sample and reference spectrum shall be concordant |
positions and relative sizes of the bands in the spectrum of the sample and reference spectrum are concordant |
B.by TLC |
It complies with the identification test for phenothiazines |
it complies with the identification test for phenothiazine |
C.Test with nitric acid |
forms orange colored solution and organge-red precipitate |
complies with test for chlorides |
pH(10% w/v solution) |
4.0-5.0 |
4.31 |
isopromethazine |
not more than 1.0% |
less than 1.0% |
other impurity |
not more than 0.5% |
less than 0.5% |
sulphated ash |
not more than 0.5% |
0.20% |
loss on drying at 105ºC |
not more than 0.5% |
0.20% |
assay |
98.5-101%(on anhydrous basis) |
100.0% |
Conclusion |
Qualified |
Description:
Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic (Histamine H1 receptors but it does not block the production of histamine) and anticholinergic properties. In some countries it is prescribed for insomnia when benzodiazepines are contraindicated. It is available in many countries under many brand names.Promethazine was developed in the mid 1940s when a team of scientists from Rhône-Poulenc laboratories were able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine.
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Promethazine Hydrochloride Active Pharmaceutical Ingredients CAS 58-33-3 Images
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