Product Name: Cyproterone acetate
English Name: Androcur; CCRIS 4385; Cyprostat; Cyproteron
acetate; Cyproteron-R acetate; Cyproterone 17-O-acetate;
Cyproterone 17alpha-acetate; HSDB 3592; NSC 81430; NSC-81430
EINECS number: 207-048-3
Molecular formula: C24H29ClO4
Molecular Weight: 416.9377
Density: 1.27g / cm3
Boiling point: 525.9 ° C at 760 mmHg
Flash Point: 177.6 ° C
Vapor Pressure: 3.78E-11mmHg at 25 ° C
Product use: Anti-androgen for the treatment of benign prostatic hyperplasia men, and are useful as male contraceptives
Appearance: white crystalline powder
Package: 1 kg/foil bag or as required
Cyproterone acetate (INN, USAN, BAN, JAN), sometimes abbreviated asnCPA, and sold under brand names such as Androcur and Cyprostat, isna synthetic steroidal antiandrogen drug with additional progestogennand antigonadotropic properties. Its primary action is to suppressnthe activity of the androgen hormones such as testosterone steroid and itsnmore potent metabolite dihydrotestosterone (DHT) in the body,neffects which it mediates via competitive antagonism of thenandrogen receptor and inhibition of enzymes in the androgennbiosynthesis pathway.
The main therapeutic indications ofncyproterone acetate are prostate cancer, benign prostaticnhyperplasia, priapism, hypersexuality (e.g., as a form of chemicalncastration), and other conditions in which androgen actionnmaintains the disease process. In addition, it can also be used tontreat acne and hirsutism in females, and is a common component innhormone therapy for transsexual women.
In addition to its antiandrogen properties, cyproterone acetate hasnweak progestogen activity (i.e., it acts like progesterone).nAccordingly, it can be used to treat hot flashes, and is also ancomponent of some combined oral contraceptive pills such asnDianette in the United Kingdom and Diane-35 in other countries suchnas Canada. It is called Dixi-35 in Chile. No form of cyproteronenacetate is available in the United States.
Until the development of leuprorelin, cyproterone acetate was onenof the few drugs used to treat precocious puberty. It was also usednin animal experimentation to investigate the actions of androgensnin fetal sexual differentiation.
CPA has been in use as an antiandrogen since 1964, and was the first antiandrogen introduced for clinical use.It is widely used throughout Europe, and is also used in Canada, Mexico, and other countries. It is not FDA-approved for use in the United States, due to concerns about hepatotoxicity; medroxyprogesterone acetate has been used in this country instead.CPA has been approved for the treatment of prostate cancer, precocious puberty, androgen-related dermatological conditions (such as acne, seborrhea, hirsutism, and androgenic alopecia), and to reduce sex drive in sex offenders.
Combination formulations of CPA with ethinyl estradiol (a formulation sometimes referred to as co-cyprindiol) have been available as contraceptives since 1997.Other uses of CPA include the treatment of benign prostatic hyperplasia, priapism, hypersexuality, paraphilias, hot flashes, and hyperandrogenism in women. In addition, with the exception of the United States (where CPA is not available and spironolactone is generally employed instead), CPA is widely used as a component of hormone replacement therapy for trans.
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