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Home > Products > Anti Estrogen Steroids > Estriol Female Anti Estrogen Steroids Raw Pharmaceutical Active Ingredients CAS
 

Estriol Female Anti Estrogen Steroids Raw Pharmaceutical Active Ingredients CAS

  • Estriol Female Anti Estrogen Steroids Raw Pharmaceutical Active Ingredients CAS
Place of Origin:
China
Brand Name:
Kafen
Certification:
GMP,ISO,UKAS
Model Number:

50-27-1

Min.Order Quantity:
As your required.
Price:
Negotiable
Packaging Details:
According to your requirements.
Delivery Time:
Within 24 hours after receiving your payment.
Payment Terms:
Western Union,Money Gram,Bank Transfer,Bitcoin
Supply Ability:
1000KG/Month
Contact Now
 

Product Description

Basic Info.

 

Estriol
Synonyms: 50-27-1, steroid powder, Estriol
CAS No.: 50-27-1
Formula: C18H24O3
Molecular Weight: 288.39
EINECS: 200-022-2
Density: 1.255 g/cm3
Melting Point: 280-282 ° C(lit. )
Boiling Point: 469 ° C at 760 mmHg
Flash Point: 220.8 ° C
Purity: 99%
Appearance: White crystalline powder


Description:

 

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.

 

Estradiol or oestradiol (American or British English usages), derives from estra-, Gk. οστρο? (oistros, literally meaning "verve or inspiration") and -diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.

 

Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.

 

Application:


Hormonal contraception:

A chemical derivative of estradiol, ethinyl estradiol with maximum dosage 200 µg, is a major component of hormonal contraceptive devices. Combined forms of hormonal contraception contain ethinyl estradiol and a progestin, which both contribute to the inhibition of GnRH, LH, and FSH, which accounts for the ability of these birth control methods to prevent ovulation and thus prevent pregnancy. Other types of hormonal birth control contain only progestins and no ethinyl estradiol.


Hormone replacement therapy:

If severe side effects of low levels of estradiol in a womans blood are experienced (commonly at the beginning of menopause or after oophorectomy), hormone replacement therapy may be prescribed. Such therapy is usually combined with a progestin to reduce the risk of endometrial cancer.

Estrogen therapy may be used in treatment of infertility in women when there is a need to develop sperm-friendly cervical mucus or an appropriate uterine lining. This is often prescribed in combination with clomifene.

 

Estrogen therapy can also be used to treat advanced prostate cancer, as well as to relieve symptoms of breast cancer.


Not all products are available worldwide. Estradiol is also part of conjugated estrogen preparations, such as Premarin, though it is not the major ingredient. (Premarin consists of a large number of estrogen derivatives. As the name indicates, it comes from pregnant mares urine.

 

Hormone replacement therapy in transgender women:

Main article: Hormone replacement therapy (male-to-female)
Estrogen therapy is also used as part of the hormone replacement therapy for trans women. Either oral or transdermal estradiol is used in higher concentrations during initial treatment and transition; estradiol is continued in lower doses to maintain female-level hormones following gender reassignment surgery.

 

Blocking estrogens:

Inducing a state of hypoestrogenism may be beneficial in certain situations where estrogens are contributing to unwanted effects, e.g., certain forms of breast cancer, gynecomastia, premature closure of epiphyses, and inhibiting feminization in female-to-male transsexual hormone treatment. Estrogen levels can be reduced by inhibiting production using gonadotropin-releasing factor agonists (GnRH agonists) or blocking the aromatase enzyme using an aromatase inhibitor, or with an estrogen receptor antagonist,.

 

COA:

 

TEST ITEMS SPECIFICATION RESULTS
Description : White or Almost White Crystalline Powder white powder
Identification : A.B. Positive
Assay : 97.0~102.0% 99.3%
Specific Rotation : +101°~+105° +102.6°
Loss On Drying : 1.0%max 0.27%
Melting Point : 153~157°C 153.0~155.0°C
Organic Volatile Impurities : meets the requirement. Conforms
Related Substances : meets the requirement. Conforms
Residual Solvents : meets the requirement. Conforms
Particle Size : 100% ≤ 20 microns Conforms
Conclusion The specification conform with USP30 standard

 

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Company Introduction:

 

(1) High Quality:Kafen Biotech is a steroids manufacturer with its own lab and factory.
The purity of our product is tested by our quality department before it is shipped to our clients. Mostly steroids are 99% purity and approved by SGS,CTI and ITS.

 

(2) Favorable Price: Our price meets international market performance and we give the best doiscounted price for our new customers and promotioned price for our regular customers.

 

(3) Safe Fast Delivery: After receiving your payment,we will have professional package team to arrange your parcel within 12 hours.We can guarantee every goods can be successfully deliveried.

 

(4) Available Shipment Way: EMS,HongKong Post,DHL,TNT,UPS,FedEx,Registered Mail,Air Express,Sea Vessel etc.

 

(5) After-Sale Service: We can offer you good service after you place an order.At the same time,we can offer you some homebrew recipe to make injection.More service is more available to you.

 

 


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