Product Name: Clotrimazole
CAS No.: 23593-75-1
Synonyms:(2-chlorophenyl) benzhydryl) imidazole; 1- (o-(2-chlorophenyl) benzhydryl) 1- (o-chlorophenyl) Chloro-alpha, alpha-diphenylbenzyl) -imidazol; 1 - [(2-chlorophenyl) benzhydryl] imidazole; 1H-Imidazole, 1 - [(2- Chlorophenyl diphenylmethyl]
Molecular Weight: 344.84
Appearance: White powder
Usage:Broad spectrum antifungal
Clotrimazole is an artificially synthetic azole antifungal agent with inhibitory effect on a variety of pathogenic fungi. It is also able to directly kill the fungi at high concentration. Clotrimazole, through interfering with cytochrome P450 activity, inhibits the biosynthesis of the fungal ergosterol and other steroids; cause damage of the fungal cell membrane and change its permeability, causing the leakage of many kinds of important material in the cell; it can also inhibit the biosynthesis of the fungal triglyceride and phosphor-lipid; the product can still inhibit the activity of oxidase and peroxidase, causing the over-accumulation of peroxides in the cell, causing the degeneration and necrosis of the fungal subcellular structures. Clotrimazole has broad-spectrum antifungal activity with excellent anti-fungal activity against Epidermophyton, Trichophyton, aspergillosis, coloring fungi, Cryptococcus and Candida species. It also has certain antifungal effect against sporothrix schenckii,blastomycosis dermatitidis, Blastomyces coccidioides as well as Histoplasma.
It has good anti-fungal effect against Candida, Cryptococcus, Aspergillus, algae bacteria, dermatophytes, etc in both in vivo and in vitro. It efficacy in treating skin superficial mycoses is similar as griseofulvin while its efficacy in treating deep fungal disease is similar as amphotericin B. It has excellent efficacy in treating visceral pathogenic fungi such as Candida albicans, Cryptococcus neoformans, coccidioidomycosis and histoplasma. Its effect on the Candida albicans is stronger than nystatin. Fungi are not easy to evolve drug resistance to this kind of product. This product is easily absorbed orally and can be used for the treatment of systemic fungal infection such as aspergillosis fumigatus, candidiasis, cryptococcosis, coccidioidomycosis, histoplasmosis (dogs, cats) and fungal septicemia. For severe fungal infection, it is preferably to use it in combination with amphotericin B. Topically it can also be used for the treatment of superficial fungal infections such as ringworm and livestock comb body and hair tinea. However, it is invalid in treating tinea capitis. Clotrimazole also has certain efficacy in treating some kinds of Gram-positive bacteria and Trichomonas vaginalis.
Suitable for the treatment of Candida albicans caused by skin candidiasis; Trichophyton rubrum, to be ringworm Trichophyton, flocculent epidermophyton and canine microsporidia due to tinea pedis, tinea corporis and tinea corporis, furfur Serratia caused by tinea versicolor, can also be used to treat paronychia, ringworm and tinea capitis.
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Clotrimazole Powder Feed Additives CAS 23593-75-1 For Broad Spectrum Antifungal Images