Chemical Properties White or almost white powder or crystal. Soluble in water, slightly soluble in ethanol, insoluble in ether. Hygroscopic, when it is set at room temperature in an aqueous solution ,it gradually turns yellow,produces turbidity, decreases potency. Odorless, slightly bitter taste.
Uses A semi-synthetic broad-spectrum penicillin,it is mainly used for treatment of penicillin-sensitive gram-positive bacteria, Escherichia coli, Proteus, Salmonella, Shigella and other.
production method It is derived from the ampicillin salifying : Ampicillin is suspended in water, adjust to pH 9 with sodium hydroxide solution, dissolve and filter . The filtrate is added active carbon, and is filtered and the filtrate is dried at a low temperature, to obtain the product.
Category Toxic substances
Toxicity grading Low toxic
Acute toxicity Oral-rat LD50:> 5314 mg/kg; Oral-Mouse LD50:> 5314 mg/kg.
Flammability and hazard characteristics Combustion produces toxic sodium oxide, nitrogen oxide and sulfur oxide gases.
Storage Characteristics Ventilated, low-temperature ,dry storeroom.
Extinguishing agent Water, dry powder, foam, sand.
Chemical Properties White powder
Uses diuretic, anti-hypertensive
1. For the treatment of sensitive enterococci, Shigella, Salmonella, E. coli, Listeria, aerogenes, Haemophilus influenzae and Proteus mirabilis.
2. Broad-spectrum semi-synthetic penicillin drugs, low toxicity. Similar antibacterial spectrum and penicillin, penicillin-sensitive bacteria lower potency, antibacterial effect viridans with penicillin similar or slightly stronger. Against diphtheria, tetanus, and actinomycetes its effectiveness and penicillin basically the same. Enterococcus and Listeria effect is better than benzylpenicillin. And it can produce drug-resistant staph bacteria penicillin had no antibacterial effect. Effective against gram-negative bacteria, but easy to produce drug resistance.
3. Mainly caused by susceptible strains of the drug for urinary system, respiratory system, biliary tract, intestinal infections and meningitis, endocarditis.
4. Mainly used for typhoid, paratyphoid treatment; also for the urinary tract, respiratory tract infections.