Product Name: Gentamycin sulfate
Synonyms: GENTAMICIN 2,5-SULFATE HYDRATE;genoptics.o.p.;gentalline;gentamicinsolution;nsc-82261;sch9724;gentamicin solution 10mg/ml sterile filtered;gentamicin solution cell culture tested
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Melting point 218-237°C
Storage temp. 2-8°C
Solubility H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days.
Chemical Properties : White to buff-colored powder
Usage : Use for the treatment of sepsis, urinary tract infections, staphylococcal infections, endocarditis and other diseases
Gentamicin sulfate is composed of amino sugar and ligands of glycosides bactericidal antibiotics, gentamicin sulfate, antibacterial spectrum and kanamycin similar. Mainly used for Escherichia coli, Shigella, Klebsiella pneumoniae, Proteus, Pseudomonas aeruginosa and other Gram-negative bacteria caused by systemic or local infection. Ophthalmology for conjunctivitis, keratitis and so on. Oral can be used for intestine infection or colonic surgery before preparation; also with metronidazole or clindamycin in combination to reduce colon infection rate.
Gentamicin sulfate on a variety of Gram-negative bacteria and Gram-positive bacteria have a good antibacterial effect on a variety of Enterobacteriaceae bacteria such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa have a good antibacterial effect. Neisseria and Haemophilus influenzae are moderately sensitive to this product. On the Brucella, Yersinia, Acinetobacter, Fetal Campy also have a role. About 80% of methicillin-sensitive strains of Staphylococcus aureus (including Staphylococcus aureus and coagulase-negative staphylococci) have good antibacterial activity, but methicillin-resistant strains are resistant to gentamicin sulfate. Streptococcus and Streptococcus pneumoniae the role of poor, Enterococcus are mostly resistant to this product. In recent years, Gram-negative bacilli significantly increased gentamicin-resistant strains. This product and β-lactam combined, the majority of access to synergistic antibacterial effect.
||3.5 to 5.5
|Specific Optical Rotation
||Not more than 1.0 percent
||C1 25.0to45.0 percent
|Cla 10.0to30.0 percent
|C2a+C2+C2b 35.0to55.0 percent
||Not more than 15.0 percent
||Not more than1.0 percent
||32.0 to 35.0 percent
||Less than 0.71IU/mg
||Not less than 590IU/mg
Use for clinical use of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Shigella, Klebsiella, Proteus and other sensitive bacteria caused by sepsis, respiratory infections, biliary tract infections, suppurative peritonitis, intracranial infection, urine Road infections and dysentery and other diseases.
The use of gentamicin binds to the 30S ribosomal subunit and causes a cryptographic readout that blocks the transfer of peptidyl-tRNA from the receptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas sp. Was combined with the outer membrane fraction of the cell membrane, replacing the originally existing cation, causing the membrane to become unstable and forming voids on the cell surface. Antibacterial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria.
The product is aminoglycoside antibiotics, has bacteriostatic and bactericidal effect on a variety of Gram-negative bacteria and gram-positive bacteria. It has better effect on Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter aerogenes, Salmonella, Escherichia coli and Proteus and other gram-negative bacteria and Staphylococcus aureus. For Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, bacillus, Klebsiella,deformation caused by bacteria and other sensitive bacterial sepsis, respiratory tract infection, biliary tract infection, suppurativeperitonitis, intracranial infection, urinary tract infection and bacillary dysentery.
1.This product is aminoglycoside broad-spectrum antibiotics, has antibacterial and bactericidal effects of various gram-negative bacteria and Gram-positive bacteria.
2.Clinically used in Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Shigella, Klebsiella, Proteus and other sensitive bacteria causing septicemia, respiratory tract infection, biliary tract infection, suppurative peritonitis, intracranial infection, urinary tract infection and bacillary dysentery diseases clinic.