Rifampin Veterinary Drugs Powder Rifampin for Treating Tuberculosis CAS:13292-46-1
||Antibiotics;Organics;Antitubercular;Antibiotics for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Peptide Synthesis/Antibiotics;Chiral Reagents;Isotope Labelled Compounds;RIFADIN;antibiotic
Several semisynthetic derivatives (rifamycin SV, rifampin [rifampicin], rifamide) of natural rifamycins have been used as extended-spectrum antibiotics. Rifamycins interfere with the synthesis of RNA in microorganisms by binding to subunits of sensitive DNA-dependent RNA polymerase. They are active against gram-positive organisms, some mycobacteria, a few strains of gram-negative bacteria (mostly cocci; bacilli are more resistant), some anaerobes, and chlamydiae. At high concentrations, they are also active against several viruses. Fungal and yeast infections resistant to rifampin alone often respond when a rifamycin is added to an antifungal agent (eg, amphotericin B). Resistance to rifamycins may develop rapidly as a 1-step process. For this reason, they should be administered in combination with other antimicrobials, such as penicillins, erythromycin, miconazole, and amphotericin B.
The primary use of the rifamycins in people has been to treat tuberculosis. Rifampin has been used in foals to control Rhodococcus equi pneumonia. Because rifamycins penetrate tissues and cells to a substantial degree, they are particularly effective against intracellular organisms. Rifampin is readily but incompletely (~40%) absorbed from the GI tract, and plasma concentrations peak within 2-4 hr. Concurrent feeding may reduce or delay absorption. Rifampin may also be administered IM or IV.
Approximately 75%-80% of rifampin is bound to plasma proteins. It is widely distributed in body tissues and fluids because of its high lipid solubility. Rifampin is biotransformed to several metabolites, some of which are active, and is primarily excreted in bile (used for cholangitis in people) and to a lesser degree in urine. Enterohepatic cycling of the parent drug and its main metabolite (desacetylrifampin) commonly occurs. The elimination half-life of rifampin is dose dependent: in horses, it is ~6 hr; in dogs, ~8 hr. The plasma half-life progressively shortens by ~40% during the first 2 wk of treatment because of the induction of hepatic microsomal enzymes; conversely, it is increased with hepatic dysfunction.
Rifampin is usually well tolerated and produces few adverse effects. GI disturbances and abnormalities in liver function (icterus) have been reported in people. Hypersensitivity reactions can also result from rifampin administration, and renal failure is a possible consequence when intermittent dosage schedules are followed. Partial, reversible immunosuppression of lymphocytes develops. Urine, feces, saliva, sputum, sweat, and tears are often colored red-orange by rifampinand its metabolites. CNS depression after IV administration and temporary inappetence are seen in horses. The dose range for rifampin in horses is 10-25 mg/kg/day, PO or parenterally.
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CAS 13292-46-1 Rifampin Veterinary Drugs Powder Rifampin for Treating Tuberculos Images