Alias : 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol
CAS register number: 154229-19-3
Molecular Formula: C24H31NO
Molecular Weight: 349.51
Appearance: White powder
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Usage: It is indicated for use in combination with prednisone as a treatment for metastatic castration-resistant prostate cancer.
Abiraterone is a new type of hormone therapy. It is also called abiraterone acetate. It is used to treat prostate cancer that has spread to other parts of the body. It may help some men to live longer. It can also help control symptoms. Clinical trials are also using abiraterone for earlier stages of prostate cancer and advanced breast cancer. Abiraterone is associated with a not uncommon rate of serum enzyme elevation during therapy, but has not been clearly linked to cases of clinically apparent liver injury with jaundice.
Abiraterone is a steroidal compound with antiandrogen activity. it is a Cytochrome P450 17A1 Inhibitor. The mechanism of action of abiraterone is as a Cytochrome P450 17A1 Inhibitor, and Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.
Abiraterone is a drug used in combination with in metastatic castration-resistant prostate cancer (formerly hormone-resistant or hormone-refractory prostate cancer) -- i.e., prostate cancer not responding to androgen deprivation or treatment with antiandrogens. It is formulated as the prodrug abiraterone acetate and marketed under the trade name Zytiga. Cadila Pharmaceuticals has recently started marketing Abiraterone acetate under the trade name Abretone.
After an expedited six-month review, abiraterone was approved by the U.S. Food and Drug Administration (FDA) in April 2011. In Phase III trials, it extended median survival to 14.8 months versus 10.9 months placebo, and the trial was stopped because of the successful outcome.
4.Hot product :
||A White or almost white crystalline powder
||Freely soluble in methylene chloride,acetone and in THF,hardly soluble in n-Heptane
||A).By IR: Positive
|B).By HPLC: Positive
|Residue on ignition
|Loss on drying
|Unspecified impurity: 0.1% max
|Total impurities: 0.5% max
|Methylene chloride: 600ug/g max
|THF: 720ug/g max
|Acetic acid:5000ug/g max
||Preserve in tight,light-resistant contaners,and store at room temperatura.
|Assay (on anhydrous basis)
||98.0% to 102.0%
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99% Purity Abiraterone Powder CAS154229-19-3 For Prostate Cancer Treatment Images