Synonym: Vetoryl, Desopan, Modrastane, Modrenal, Triwinol, Win-14540
CAS Registry Number: 13647-35-3
Einecs No: 237-133-0
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: : White crystalline powder
Delivery time: Within 18 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage: Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.
heart liver kidney and bone marrow transplant patients preferred immune-suppressing drugs after the transplant rejection resistant to conventional immunosuppressive regimen, is also the choice of the drug... Adverse reactions similar to cyclosporine. autoimmune eye disease and other autoimmune diseases also play an active role.
Trilostane is used in the treatment of Cushings syndrome. It is normally used in short-term treatment until permanent therapy is possible.
Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushings syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5, 4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Side effect: Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
||257°C to 270°C
||White to pale white solid
||No more than 20ppm
|Loss on drying
||Not more than 0.5%
|Residue on Ignition
||Not more than 0.1%
||soluble in dimethyl sulfoxide
|soluble in pyridine
|slightly soluble in ethanol
|slightly soluble in water
||Not less than 99.0%
||not more than 1.0%
||not less than 99.0%
||Comply with In-house standard.
||Store protected from light and moisture
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Store in cool and dry area and keep away from direct sunlight.oC
2 years, keep in formal storage condition.
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99% Purity Raw Material Trilostane Powder CAS 13647-35-3 For Breast Cancer Images