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Home > Products > Local Anesthetic Drugs > 99% USP Standard Local Anesthetic Drugs Tetracaine HCL Raw Powder CAS136-47-0
 

99% USP Standard Local Anesthetic Drugs Tetracaine HCL Raw Powder CAS136-47-0

  • 99% USP Standard Local Anesthetic Drugs Tetracaine HCL Raw Powder CAS136-47-0
Place of Origin:
China
Brand Name:
Kafen
Certification:
GMP
Model Number:

136-47-0

Min.Order Quantity:
10g
Price:
Negotiable
Packaging Details:
Discreet and disguised
Delivery Time:
Within 24 hours after receiving your payment
Payment Terms:
Western Union, MoneyGram,Bitcoin and Bank Transfer
Supply Ability:
5000KG/Month
Contact Now
 

Product Description

Tetracaine hydrochloride 
Synonyms: L AND OCAIN HYDROCHLORIDE; INTERCAIN HYDROCHLORIDE;
Product Categories: API intermediates; Sodium channel; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals
CAS: 136-47-0
Purity: 99%
Appearance: White powder
Package: 25kg/cardboard
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
Melting point: 147~150Celsius
Usage: Being used as Local anesthetics, It mainly used as mucosal anesthesia.

 

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.


In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

 

Application:

 

Tetracaine HCL is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction.


Tetracaine Hcl is a potent local anesthetic of the ester group.It is mainly used topically in ophthalmology and as an antipruritic,and it has been used in spinal anesthesia.


Tetracaine hydrochloride is indicated for the production of spinal anesthesia for procedures requiring two to three hours.

 

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine,though, has the advantage of a rapid onset of action.


In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.

 

COA:

 

Items QUALITY STANDARDS RESULTS

Description

White or almost white crystalline powder

White crystalline
powder

Solubility

Matching with the working standard

Complies
 
A.By IR, To match with working standard

Complies

Identification

B: To 10ml of solution S add 1ml of ammonium thiocyanate solution
R.A white,crystalline precipitate is formed which,after recrystallisation
from water R and drying at 80ºC for 2h,melts at about 131ºC

Complies
 
C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to
dryness on a waterbath,allow to cool and dissolve the residue in
5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.
A violet colour develops

Complies
 
D. Solution S gives reaction of chlorides.

Complies

PH

4.5~6.5

5.78

Residual Solvents

Conform to standard

Complies

Claruty

Solution should be clear

Complies

Related Substances

Conform to standard

Complies

Heavy metals

≤10ppm

<10ppm

Loss on drying

≤1.0%

0.87%

Resiue on ignition

≤0.1%

0.05%

Melting range

148ºC

147.5ºC~150.8ºC

Assay(*)

99%~101.0%

100.40%

 

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99% USP Standard Local Anesthetic Drugs Tetracaine HCL Raw Powder CAS136-47-0 Images

 

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