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Home > Products > Local Anesthetic Drugs > Local Anesthetic Raw Materials Procaine in White Crystalline Powder CAS 59-46-1
 

Local Anesthetic Raw Materials Procaine in White Crystalline Powder CAS 59-46-1

  • Local Anesthetic Raw Materials Procaine in White Crystalline Powder CAS 59-46-1
Place of Origin:
China
Brand Name:
Kafen
Certification:
GMP,ISO,UKAS
Model Number:

59-46-1

Min.Order Quantity:
10g
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Negotiable
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Supply Ability:
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Product Description

 

Local Anesthetic Raw Materials Procaine in White Crystalline Powder CAS:59-46-1


Basic Info.

Product name: Procaine
Alias: Procaine hydrochloride; Aminocaine; Anadolor; Atoxicocaine;
CAS register number: 59-46-1
Molecular formula: C13H21ClN2O2
Molecular weight: 236.31
Appearance: White crystalline powder

 

Description:

 

Procaine hydrochloride, also called Novocain, synthetic organic compound used in medicine as a local anesthetic. It became the first and best-known substitute for cocaine in local anesthesia. Generally used in a 1 to 10 percent saline solution, procaine hydrochloride is administered by injection for infiltration (area flooding as in dental anesthesia), nerve-block, spinal, and caudal anesthesia. Unlike cocaine, procaine is not toxic, addicting, or irritating. It has been displaced somewhat by the chemically related drugs lidocaine and mepivacaine, which produce prompter, more intense anesthesia.

Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.

The routes of administration and concentrations are: for local infiltration use 0.25% to 0.5% (via dilution) and for peripheral nerve blocks use 0.5% (via dilution), 1%, and 2%. (See DOSAGE AND ADMINISTRATION for additional information.)

 

Application:

 

Procaine is a local anesthetic. Procaine causes loss of feeling of skin and mucous membranes.Procaine is used as an injection during surgery and other medical and dental procedures.Procaine may also be used for purposes other than those listed here.

 

Procaine is a chemical. People use it for medicine. Be careful not to confuse the procaine used by mouth with the prescription procaine given by injection only under the supervision of a healthcare professional.

Procaine is taken by mouth or given as a shot for arthritis, “hardening of the arteries” in the brain, dementia, depression, hair loss, high blood pressure, and sexual performance problems.As a prescription-only injection, procaine is used for local anesthesia.


Usage:

 

Procaine is a kind of local anesthetics. With low toxicity but quick and safe effects, procaine is suitable for local anesthesia, applied to the eye, ear, nose, teeth and other department operation, used for infiltration anesthesia, anesthesia and closed therapy supervisor. Procaine is also used in the production of procaine penicillin.

 

Specifications:

 

Test Items Specification Test Results
Appearance White crystals or a white crystalline powder Conform
Identification ABE. It appears positive reaction
Melting point 154degree~158degree 154degree~157degree
Acidity PH 5.0~6.5 PH=5.9
Appearance of solution Clear and colourless Conform
Loss on drying ≤0.5% 0.07%
Heavy metals ≤0.0005% Conform
Related substances ≤0.05% Conform
Sulphated ash ≤0.1% 0.05%
Assay ( on dry basis ) 99.0-101.0% 99.87%
Conclusion Conform to BP2005

 

Side effects:

Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.[8] Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.

Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 white North Americans are homozygotic (i.e. they have two copies of the abnormal gene) for the commonest atypical form of the enzyme pseudocholinesterase,[10] which means that they do not hydrolyze ester anesthetics such as procaine. The results in a prolonged period of high levels of the anesthetic in the blood and increased toxicity. However, there are populations in the world, such as the Vysya community in India, where deficiency of this enzyme is much more common.
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Related Products:

 

Benzocaine CAS: 94-09-7
Lidocaine CAS: 137-58-6
Propitocaine hydrochloride CAS: 1786-81-8
Tetracaine hydrochloride CAS: 136-47-0
Procaine hydrochloride CAS: 51-05-8
Pramoxine hydrochloride CAS: 637-58-1
Tetracaine CAS: 94-24-6
Proparacaine hydrochloride CAS: 5875-06-9
PROCAINE CAS: 59-46-1
Benzocaine hydrochloride CAS: 23239-88-5
Lidocaine hydrochloride CAS: 73-78-9
Articaine hydrochloride CAS: 23964-57-0
Levobupivacaine hydrochloride CAS: 27262-48-2
Ropivacaine hydrochloride CAS: 132112-35-7
Dibucaine hydrochloride CAS: 61-12-1
Bupivacaine hydrochloride CAS: 14252-80-3
Articaine CAS: 23964-58-1

 

 


Local Anesthetic Raw Materials Procaine in White Crystalline Powder CAS 59-46-1 Images

 

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