Name: Ibutamoren mesylate(MK-677)
Molecular Weight: 624.77
Boiling Point: 868.9 °C at 760 mmHg
Appearance: white powder
Storage: At room temperature
Application: active growth secretagpgie ,mk-677 Effective for age -related fraity Active
||White to yellowish-white crystalline powder
||32 ~ 37ºC
|Specific optical rotation
|Loss on drying
||97 ~ 103%
|Free heptanoic acid
||The specification conform with enterprise standard
Nutrobal (Mk-677) is an orally administrated growth hor secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hor . In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active secretagogue,mimicking the GH stimulating action of the endogenous hormone ghrelin.It has been demonstrated to increase the release of, and producessustained increases in plasma levels of several hormones including , but without affecting cortisol levels.
It is currently under development as a potential treatment for reduced levels of these hormones, such as
in deficient children or elderly adults, and human studies have shown it to increase both muscle mass
and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly.It also
alters metabolism of body fat and so may have application in the treatment of obesity.Some mk-677 study shows the suggested mk-677 dosage is 25mgs-50mgs when it is the oral.
Produced by Reverse Pharmacology, MK 677 (Nutrobal) is an orally administered growth hormone secretagogue that is designed to stimulate the pituitary gland to release growth hormones. In case youe
wondering, "secretagogue" is basically a natural substance that causes another substance to be
secreted, such as gastrin.
MK 677 (Nutrobal) was originally formulated to keep health problems like osteoporosis, obesity and
muscle wasting, but has been seen to promote an increase in lean body mass as well as a boost in
IGF-1 serum concentration during clinical runs.
Moreover, here are the positive effects of MK 677 (Nutrobal) in terms of improving growth hormone
pulse intensity:Inhibits the signaling of somatostatin receptors.Slows down the activity of somastostatin in the system.Improves somatotroph signaling in growth hormone releasing hormones (GHRH).Amplifies and increases the overall production and release of GHRH
Health Benefits of Ibutamoren(MK-677)
1. Ibutamoren (MK-677)Helps Build Muscles
Ibutamoren is frequently used as an anabolic substance, to increase lean body mass i.e. create bigger muscles. It is orally active and can be taken once a day. These are all benefits compared with other growth GH hormone stimulators.
In healthy obese men, a two-month treatment with ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR) .
2. Ibutamoren (MK-677)Reduce Muscle Wasting
In food-deprived healthy volunteers, ibutamoren reversed diet-induced protein loss , that could cause muscle wasting.
In elderly patients with hip fracture, ibutamoren improved gait speed, muscle strength and reduced the number of falls .
3. Ibutamoren (MK-677)Increases Bone Density
Growth GH hormone increases bone turnover and eventually bone density . However, because of the increased turnover in subjects treated with growth GH hormone, bone density can initially decrease before increasing . Basically, it takes time (> 1 year) to see the bone density increase.
In healthy obese male volunteers, ibutamoren increased bone turnover .
In elderly adults, ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover .
In post-menopausal women, ibutamoren increased bone mineral density, which helps increase bone strength and prevent osteoporosis .
4. Ibutamoren (MK-677)Improves Sleep
A study showed that in both younger and elderly subjects, ibutamoren improved sleep quality and REM (rapid eye movement) sleep duration .
Apart from scientific studies, there have been many reports of subjective improvements in sleep quality, across various online forums.
5. Ibutamoren (MK-677)Combats Aging and May Increase Longevity
Growth GH Hormone secretion and muscle mass both decline from mid-puberty throughout life.
In another study, ibutamoren rejuvenated the growth GH hormone profile in obese subjects .
6. Ibutamoren (MK-677)May Have Nootropic Effects
Some people use ibutamoren as a nootropic because it acts on the ghrelin receptor, which has nootropic effects. You can read more about these effects in the post on ghrelin. Science is, however, yet to study if and how ibutamoren affects cognitive performance.
Two indirect mechanisms by which ibutamoren can improve brain function:
Ibutamoren also increases REM sleep duration and sleep quality . And we know that sleep is essential for good cognitive function .
7. Ibutamoren (MK-677)is Beneficial in Treating Growth GH Hormone Deficiency
8. Ibutamoren (MK-677)May Help with Wound Healing and Tissue Regeneration
Growth GH hormone increases tissue regeneration and wound healing (R, R), so ibutamoren may help with these.
There are individual reports of ibutamoren being helpful, but scientific studies are lacking.
9. Ibutamoren (MK-677)May Help with Hangovers
This one is anecdotal, but people report curing hangovers with ibutamoren.
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