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Home > Products > SARM Steroids > AICAR Acadesine Raw SARM Steroid White Solid Raw Powder CAS 2627-69-2 For Body
 

AICAR Acadesine Raw SARM Steroid White Solid Raw Powder CAS 2627-69-2 For Body

  • AICAR Acadesine Raw SARM Steroid White Solid Raw Powder CAS 2627-69-2 For Body
Place of Origin:
China
Brand Name:
Kafen
Certification:
GMP,ISO,UKAS
Model Number:

2627-69-2

Min.Order Quantity:
10g
Price:
Negotiable
Packaging Details:
As your request
Delivery Time:
Within 24 hours after receiving your payment
Payment Terms:
T/T, Western Union, MoneyGram,Bitcoin
Supply Ability:
5000KG/Month
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Product Description

 

Supply AICAR Acadesine Raw SARM Steroids For Body Building White Solid Raw Powder CAS:2627-69-2

 

Basic info.

 

Product Name: AICAR
Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Usage: pharmaceutical intermediates.For the treatment of cardiovascular diseases.


Product Description:

 

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro

 

Product Applications:

 

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research.

 

Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).

 

The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

 

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.

AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes.

 

It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

Protect against ischemic Injury:


Interestingly,aicar has been shown to protect against ischemic injury.This type of injury is directly related to the restriction of blood to tissues,which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive.This can lead to thrombosis,embolisms,and vasoconstriction.Aicar can be used as a stabilizing peptide for ischemic episodes,and it can allow for proper blood flow to the myocardium (heart).This function is very interesting,as aicar could be fundamentally used to treat the heart muscle in the aftermath of a heart attack.This might reduce the possibility for ischemic injuries.Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide aicar,which is a downside.

Functions:


AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha.In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research.Additionally,research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase),and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside,and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).AICAR is an inhibitor of Hsp90,mTOR and p70 S6 Kinase.

 

Related Products:

 

Product name CAS No. Specification
Ostarine(MK2866) 841205-47-8/1235370-13-4/1202044-20-9 99%min
LGD-4033 1165910-22-4 98%min
MK-677 159633-92-8 98%min
Andarine (S-4) 401900-40-17 98%min
GW-501516 317318-70-0 98%min
AICAR 2627-69-2 98%min
RAD140 1182367-47-0 98%min
SR9009 1379686-30-2 98%min
YK11

1370003-76-1

 

Competitive Advantage:


1. Rich experience.
Having been specialized in this field for years, we have rich experience and widespread sales network around the word. Our steroid and hormones have been exported to overseas, like Europe, Africa, Asia, America and other countries. We are not got good feedback from our guest, but also established long business relationship with them.


2. Great quality and high purity.
Good quality is one secret for our success. All of our products enjoys high purity. Thus, it can make sure our clients need. Welcome order the samples, MOQ just 10 grams.


3. Safest and fastest delivery.
We have mass stock, so that we can arrange the delivery within 24hours once receiving the payment. Tracking number would be informed quickly after shipment. We have our own way of packing which could ship 0.01 kilo to 50 kilo products a time.


4. Good after-sales service.
24/7 is available. We will tell you the package updated info ASAP. And try our best to solve various problems customers encountered!


5. Experiential shopping
Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how to make hormone solution on the site. Any visit to our lab is welcomed.

 


AICAR Acadesine Raw SARM Steroid White Solid Raw Powder CAS 2627-69-2 For Body Images

 

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