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Home > Products > SARM Steroids > Pharmaceutical Intermediate AICAR / Acadecine Powder CAS 2627-69-2 White Color
 

Pharmaceutical Intermediate AICAR / Acadecine Powder CAS 2627-69-2 White Color

  • Pharmaceutical Intermediate AICAR / Acadecine Powder CAS 2627-69-2 White Color
Place of Origin:
China
Brand Name:
Kafen
Certification:
GMP,ISO,UKAS
Model Number:

2627-69-2

Min.Order Quantity:
10g
Price:
Negotiable
Packaging Details:
According to your requirements
Delivery Time:
Within 24 hours after receiving your payment
Payment Terms:
West Union,Moeny Gram, Bitcoin and Bank Transfer
Supply Ability:
5000KG/Month
Contact Now
 

Product Description

1.Basic info.

 

Product Name: AICAR
Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Usage: pharmaceutical intermediates.For the treatment of cardiovascular diseases.


2.Product Description:

 

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro

 

3.Product Applications:

 

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research.

 

Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).

 

The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

 

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.

AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes.

 

It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

4.Related Products:

 

Product name CAS No. Specification
Ostarine(MK2866) 841205-47-8/1235370-13-4/1202044-20-9 99%min
LGD-4033 1165910-22-4 98%min
MK-677 159633-92-8 98%min
Andarine (S-4) 401900-40-17 98%min
GW-501516 317318-70-0 98%min
AICAR 2627-69-2 98%min
RAD140 1182367-47-0 98%min
SR9009 1379686-30-2 98%min
YK11

1370003-76-1

 

 

Shipping & Delivery
1.Packages are generally dispatched within approximately 2 days after receipt of payment.
2.After the each shipping we will provide you with:
1) a link & tracking number to track your package online.
2) the few pictures with your order & details.
3.About the Custom clearance,we packed in disguise ways.In our experience,the appropriate and safe delivery,there won be problems.
4.We confirm 99% clearance,100% resending.
5.Is it the best & safest shipping for all our repeat customers!


Packing Details
Discreet packing ways as your requirement, 100% go through.
Storage
Store in cool and dry area and keep away from direct sunlight.oC
Shelf life
2 years, keep in formal storage condition.
 
MOQ
We accept any Qty you require, grams to kilograms.
Samples Available, Contact now!
 
Top reason why you choose us ?
(1)Fast discreet delivery with great shipping success!
(2)Pictures with your order & details!
(3)We will provide you the tracking number!
(4)Keep track of your goods untill the goods are sent in to your hands.
(5)We confirm 99% clearance,100% resending.
(6)High quality,100% pure products!
(7)Delivery time approx.4-6 business days.
(8)Best, Safe and Secure services.
(9)Customer support 24/7.


Order infos
Payment Methods:West Union,Moeny Gram, Bitcoin and Bank Transfer.
Delivery Ways:EMS,HKEMS,TNT,DHL,FedEX,UPS etc.
Shipment Time:Within 12 hours after confirmation of your payment
Other Service:Safe shipment,high purity and best price for you.


Pharmaceutical Intermediate AICAR / Acadecine Powder CAS 2627-69-2 White Color Images

 

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