CAS No: 224785-91-5
Half life: 4-5 hours
Appearance: white powder, odorless, taste bitter and astringent soluble in water and alcohol.
Storage: in a cool and dry well-closed container and in ventilated area.
Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafils indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atoms position and the change of sildenafils piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafils relatively short effective time is comparable to but somewhat longer than sildenafils.
Beyond its indications for erectile dysfunction, vardenafil may be effective in the treatment of premature ejaculation, where it may significantly increase the time from vaginal penetration to ejaculation.
Vardenafil, as with all PDE5 inhibitors, should not be used by men taking nitrate medications, because combining them with vardenafil might provoke potentially life-threatening hypotension (low blood pressure).
Further, Vardenafil causing lengthening of the QT interval. Therefore it should not be taken by men taking other medications that affect the QT interval (such as amiodarone).
||White or almost white crystalline powder
||White crystalline powder
||Only one spot
||Only one spot
|Loss on drying
Vardenafil:The average working time is 15 to 30 minutes,the side effects are small.However, due to individual differences, there are still less than 2% of people will feel a slight headache. Soluble in water and ethanol.
Vardenafil hydrochloride Recommended dose:
Suggested starting usage is 10mg ,need use it 25-60minutes before having sex.
In clinical trials, having sex to take 4 to 5 hours before, still display effect.Medication frequency limit for once a day. ,not affected by eating.Need to sexual stimulation effect to make this product effect
The dosage is from 5 to 20 mg/day, according to the constitution of different dosage. Adjust the dosage according to the different physical.
child-pugh A :Don need to adjust the dosage
child-pugh B:As Vardenafils clearance to reduce, advice start from 10mg,then according to the tolerability and efficacy gradually increased to 10 mg.
child-pugh C:Research has not yet been.Not Recommended.
2. Renal damage
Patients of mild, moderate or severe renal impairment don need to adjust the doseage.
Vardenafil of dialysis patients pharmacokinetic research has not yet been performed.
As sometimes use Vardenafil and Alpha blockers together may result in symptomatic hypotension,so
drug combination just only applicable to patients accept alpha blockers treatment in stable condition.They start dose is 5mg.
As having sex with a certain degree of heart risk, then dcotor should first consider his heart condition before taking any treatment on patients with erectile dysfunction.
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