Product Name: Flibanserin
Chemical Name: Centrophenoxine HCL
CAS Number: 167933-07-5
EINECS Number: 222-975-3
Molecular Formula: C20H21F3N4O
Molecular Weight: 294.17
Melting Point: 139-143℃
Appearance: White powder
Flibanserin is a novel, non-hormonal drug that has been studied in clinical trials for the treatment of HSDD in premenopausal and postmenopausal women. The application submitted to the FDA is for premenopausal women. Flibanserin is believed to work on key neurotransmitters, or chemicals, in the brain that affect sexual desire. More specifically, it is thought that flibanserin corrects an imbalance of levels of these neurotransmitters by increasing dopamine and norepinephrine (both responsible for sexual excitement) and decreasing serotonin (responsible for sexual inhibition). In clinical studies, flibanserin was evaluated for its ability to increase the frequency of satisfying sexual events, increase the intensity of sexual desire and decrease the associated distress women feel from its loss.
Flibanserin is being hailed as "Viagra for women." The experimental drug - designed for post-menopausal women with low sex drives - has now won approval from an advisory panel for the Food and Drug Administration (FDA).
Flibanserin is an antidepressant that failed to help depression in clinical trials, but was noted to have improved sexual health outcomes. It’s not uncommon for a drug to be developed for one purpose, then approved for another. Sildenafil (Viagra) was originally developed to lower blood pressure, but failed those trials. The benefit of both of these drugs was discovered by accident. However, flibanserin has now been studied for its effects on sexual health for nearly a decade.
Flibanserin doesn have any interactions with hormonal medications, Thorp says. It does seem to interact with the original libido helper, though: some panelists recommended a warning against drinking alcohol while taking it, Reuters reported. (Interested in natural alternatives to hormone replacement therapy? The Natural Menopause Solution has everything you need to tame symptoms and trigger rapid, healthy weight loss in menopausal women.)
HSDD is the most commonly reported form of female sexual dysfunction. HSDD is defined as a persistent or recurrent deficiency or absence of sexual fantasies and desire for sexual activity that causes marked distress or interpersonal difficulty, and which is not better accounted for by a medical, substance-related, psychiatric (e.g., depression) or other sexual condition. The cause of HSDD is believed to involve a multitude of social, psychological and biological factors and may be attributed to
a complex interplay of these factors.
A new drug designed to boost sexual desire in women is controversial for some and eagerly awaited by others, but its hit a potentially serious snag. The drug didn boost womens desire any more than a placebo in two clinical trials. The Food and Drug Administration posted the clinical trial results on its website today in advance of a committee meeting on Friday, when a panel of experts will vote whether or not to recommend approval of the drug called flibanserin. (The FDA usually follows the recommendations of its expert panels.) Although there was a slight increase in the number of sexually satisfying events flibanserin users had each month, the FDA staff who reviewed the results said the so-called response rate isn "particularly compelling."
What is Flibanserin:
Flibanserin, sold under the trade name Addyi, is a medication approved for the treatment of pre-menopausal women with hypoactive sexual desire disorder (HSDD). The medication increases the number of satisfying sexual events per month by about one half over placebo from a starting point of about two to three.The certainty of the estimate is low.The side effects of dizziness, sleepiness, and nausea occur about three to four times more often.This medication is used to treat women who have not gone through menopause who have low sexual desire and are concerned about it.
Flibanserin should not be used to treat low sexual desire caused by: a medical or mental/mood disorder, problems in the relationship, or the effects of other drugs. This medication should not be used by women who have gone through menopause, or by men. Flibanserin is not used to enhance sexual performance.
How Does Sex Steroid Hormones Flibanserin Work:
Flibanserin works on three important brain chemicals: dopamine, norepinephrine, and serotonin. These chemicals are neurotransmitters. They are responsible for sending signals between the brain and other parts of the body through the nervous system.
Dopamine and norepinephrine are involved with sexual excitement. However, serotonin contributes to sexual inhibition and may dampen sex drive. It is thought that if these chemicals are out of balance – if dopamine and norepinephrine levels are too low and/or serotonin levels are too high – a woman might feel less sexual desire.
Flibanserin works by raising levels of dopamine and norepinephrine while lowering levels of serotonin. In this way, chemicals that help promote sexual desire are increased and one that can suppress desire is decreased.
Flibanserin is a pill to be taken once a day at bedtime.
Flibanserin Dosage Recommand:
(1) Recommended dosage is 100 mg taken once daily at bedtime.
(2) Taking it at night reduces the risk of sleepiness, low blood pressure, and fainting during waking hours.
(3) If your symptoms do not improve after 8 weeks of treatment, stop treatment and call your doctor.
(4) If a dose is missed at bedtime, take the next dose at bedtime the following day. Do not take a double
dose to make up for a missed one.
Flibanserin Usage Attention:
* Do NOT drink alcohol while taking Flibanserin
* Severe hypotension and syncope can oalso ccur when Addyi is used with moderate or strong CYP3A4
inhibitors or in patients with hepatic impairment; therefore, Addyi use in these settings is contraindicated.
* Do not take more or less of it or take it more often than prescribed. I mean, you`d better to consult
your doctor before take Flibanserin.
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